Endocrine Abstracts

It is now recognized that vitamin D influences the innate immune system and recent studies have highlighted the importance of local synthesis of 1,25-dihydroxyvitamin D (1,25D) for these responses. Production of 1,25D from 25-hydroxvitamin D (25D) is catalyzed by 25-hydroxyvitamin D 1α-hydroxylase (CYP27B1; 1α-OHase). Vitamin D is metabolized by 24-hydroxylase (CYP24A1; 24-OHase). A key part of the innate immune response is pathogen recognition by the toll-like recep...

Objective: The aim of this study was to compare psychological symptoms between diabetic patients, asthmatics and healthy individuals and also to determine the effect of these and other variables on quality of life among diabetes patients.Method: For each respondent the questionnaire on socio-demographic and clinical variables was completed. Each respondent also completed the General Health Questionnaire (GHQ 30), Zung’s Self Rating Depression Scale ...

We have recently demonstrated expression of a functional calcium sensing receptor (CaSR) in human aortic smooth muscle cells (HAoSMC) and human arteries and demonstrated a correlation between CaSR expression and medial calcification (a major cause of cardiovascular mortality in chronic kidney disease). Apoptosis of vascular SMC occurs early in the development of calcification and apoptotic bodies accumulate calcium. Here, we have examined CaSR-mediated signalling pathways in H...

Background: Non-functioning pituitary adenomas (NFPAs) are the most common pituitary macroadenomas with a prevalence of 7-22 per 100,000 population. As they are non-secretory, they tend to present late with visual disturbances, headaches or hormonal deficiencies. Surgery is the main treatment for NFPAs, particularly endoscopic transsphenoidal surgery which can be associated with surgical and endocrine complications.Aims: To compare pre- and post-operativ...

Reduced renal synthesis of 1,25-dihydroxyvitamin D (1,25(OH)2D) from 25-hydroxyvitamin D (25OHD) in end stage renal disease (ESRD) results in low serum 1,25(OH)2D. This appears to be due to reduced renal cell function and elevated serum fibroblast growth factor 23 (FGF23). Treatment strategies have therefore focussed on 1,25(OH)2D or its synthetic analogues, alfacalcidol or paricalcitol. However this overlooks 25-hydroxyv...

Background: Diabetes Mellitus (DM) is increasing in prevalence worldwide. Sex differences in glycaemia attainment may be relevant in the management of type 2 DM.This study determined gender differences in glycaemic targets in patients with type 2 diabetes attending the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile- Ife.Method: This cross-sectional descriptive study involved fou...

Background: A case report of Nigeria male who presented on account of bilateral gynaecomastia and was found to be azoospermic on investigation with a view to draw attention of clinicians to underling endocrine problems associated with gynaecomasia.Methodology: A case report of a 32 year old Nigeria man with progressive-bilateral breast enlargement was reviewed.Case report: A 32 year old Nigeri...

Reduced renal synthesis of 1,25-dihydroxyvitamin D (1,25(OH)2D) from 25-hydroxyvitamin D (25OHD) in end stage renal disease (ESRD) results in low serum 1,25(OH)2D. This appears to be due to reduced renal cell function and elevated serum fibroblast growth factor 23 (FGF23). Treatment strategies have therefore focussed on 1,25(OH)2D or its synthetic analogues, alfacalcidol or paricalcitol. However this overlooks 25-hydroxyv...

Background: Diabetes Mellitus (DM) is increasing in prevalence worldwide. Sex differences in glycaemia attainment may be relevant in the management of type 2 DM.This study determined gender differences in glycaemic targets in patients with type 2 diabetes attending the Obafemi Awolowo University Teaching Hospital Complex (OAUTHC), Ile- Ife.Method: This cross-sectional descriptive study involved fou...

Background: A case report of Nigeria male who presented on account of bilateral gynaecomastia and was found to be azoospermic on investigation with a view to draw attention of clinicians to underling endocrine problems associated with gynaecomasia.Methodology: A case report of a 32 year old Nigeria man with progressive-bilateral breast enlargement was reviewed.Case report: A 32 year old Nigeri...